"Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs."
The study of the design and synthesis of pharmaceuticals and the interaction of chemicals with biological systems.
Basic principles of medicinal chemistry: Introduction to medicinal chemistry, drug discovery and design, the role of medicinal chemistry in drug development.
Drug molecules and their properties: Molecular structure and properties of drugs, physicochemical properties of drugs like solubility, partition coefficient, pKa, etc.
Drug metabolism: Introduction to drug metabolism, Phase I and Phase II drug metabolisms, biotransformation of drugs in the body.
Pharmacokinetics & Pharmacodynamics: Principles of ADME (Absorption, Distribution, Metabolism, and Excretion) in drug discovery, basic concepts in pharmacodynamics, quantitative structure-activity relationships (QSAR), drug-receptor interactions.
Chemical bonding and molecular properties: Basic principles of chemical bonding in drug development, concepts of molecular and electronic properties of drugs, computational chemistry in drug discovery.
Organic chemistry: Basic concepts in organic chemistry including functional groups, reaction types, and mechanisms, stereochemistry, and enantiomers.
Bioorganic chemistry: Principles of bioorganic chemistry like enzymes, proteins, and biosynthesis of natural products, synthetic approaches for the preparation of bioactive molecules.
Medicinal chemistry of diseases: Discussion of medicinal chemistry principles in the treatment of different diseases like pain, cancer, cardiovascular diseases, and infectious diseases.
Natural product-derived drugs: The study of medicines derived from natural sources like plants, marine organisms, and microorganisms.
Chemistry of drug design: Structure-based drug design, high-throughput screening (HTS), and combinatorial chemistry in drug development.
Peptide and protein-based drugs: The chemistry of peptides and proteins as drug targets, design and synthesis of protein-coding genes and gene therapies, drug conjugates.
Drug targets and receptors: Introduction to relevant targets and receptors like enzymes, ion channels, G-protein coupled receptors (GPCRs), and nuclear receptors.
Pharmaceutical formulation chemistry: Introduction to pharmaceutical dosage forms and their properties, principles of formulation design, drug delivery systems.
Regulatory and safety issues: Assessment and regulation of drugs, safety pharmacology, and toxicology in drug discovery.
Emerging topics in medicinal chemistry: Discussion of emerging topics like nanomedicine, biophysical techniques, and personalized medicine.
Case studies: Case studies on drug discovery and development in the context of specific diseases or drug classes.
"Medicinal chemistry involves the identification, synthesis, and development of new chemical entities suitable for therapeutic use."
"It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR)."
"Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry."
"Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules and 'biologics.'"
"e.g., atorvastatin, fluticasone, clopidogrel"
"e.g., infliximab, erythropoietin, insulin glargine"
"Medicines can also be inorganic and organometallic compounds, commonly referred to as metallodrugs."
"The discipline of Medicinal Inorganic Chemistry investigates the role of metals in medicine (metallotherapeutics), which involves the study and treatment of diseases and health conditions associated with inorganic metals in biological systems."
"There are several metallotherapeutics approved for the treatment of cancer, antimicrobials, diabetes, broad-spectrum antibiotic, bipolar disorder."
"Other areas of study include: metallomics, genomics, proteomics, diagnostic agents, and radiopharmaceuticals."
"Medicinal chemistry in its most common practice—focusing on small organic molecules—encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology, and structural biology."
"Together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use."
"Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products."
"At the biological interface, medicinal chemistry combines to form a set of highly interdisciplinary sciences, setting its organic, physical, and computational emphases alongside biological areas such as biochemistry, molecular biology, pharmacognosy and pharmacology, toxicology, and veterinary and human medicine."
"These, with project management, statistics, and pharmaceutical business practices, systematically oversee altering identified chemical agents such that after pharmaceutical formulation, they are safe and efficacious, and therefore suitable for use in the treatment of disease."