"Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with designing and developing pharmaceutical drugs."
Discussion of medicinal chemistry principles in the treatment of different diseases like pain, cancer, cardiovascular diseases, and infectious diseases.
Introduction to Medicinal Chemistry: This topic provides a basic overview of the subject, including the role of medicinal chemistry in drug discovery, design, and development.
Drug Target Identification: This topic covers various techniques used to identify specific targets in the body for drug development, and the importance of selecting the right target for a particular disease.
Molecular Drug Design: This topic focuses on the process of designing novel drug molecules based on their molecular structure and the requirements for a successful therapeutic intervention.
Drug Synthesis: This topic covers the different methods employed to synthesize active pharmaceutical ingredients (APIs) and drug candidates.
Structure-Activity Relationships (SARs): This topic discusses the importance of understanding the relationship between the structure of a molecule and its biological activity, and how this knowledge can be used to design better drugs.
Pharmacokinetics and Pharmacodynamics: This topic provides an overview of how drugs are absorbed, distributed, metabolized, and excreted by the body, and how they interact with their target proteins to produce a therapeutic effect.
Drug Delivery Systems: This topic covers the different methods used to deliver drugs to their target tissues, including oral, intravenous, topical, and inhalation routes.
Drug Safety and Toxicity: This topic discusses the importance of assessing the safety and toxicity of drugs during preclinical and clinical development, and the various tests and evaluations that are performed.
Clinical Trials: This topic covers the different phases of clinical trials, including study design, patient selection, data collection and analysis, and regulatory approval.
Drug Approval and Marketing: This topic provides an overview of the regulatory framework governing drug development and approval, including the roles of organizations such as the FDA and EMA.
Intellectual Property and Patenting: This topic covers the various types of intellectual property that can be generated during drug development, and the importance of protecting these assets through patents and other legal mechanisms.
Medicinal Chemistry of Specific Diseases: This topic spans a wide range of diseases and covers the drug discovery and development process for specific diseases such as cancer, diseases of the central nervous system, infectious diseases, cardiovascular diseases, respiratory diseases, etc.
Anti-cancer Medicinal Chemistry: Anti-cancer medicinal chemistry involves the discovery and development of chemical agents that target cancer cells. These chemical agents may be small molecules like drugs or peptides that target specific proteins, pathways or signaling cascades associated with cancer cells.
Anti-inflammatory Medicinal Chemistry: Anti-inflammatory medicinal chemistry involves the development of drugs that target inflammation, which is involved in many diseases such as arthritis, asthma, and cardiovascular disease.
Anti-infective Medicinal Chemistry: Anti-infective medicinal chemistry involves the discovery and development of drugs that target infectious diseases like bacterial, viral, fungal or parasitic infections.
Cardiovascular Medicinal Chemistry: Cardiovascular medicinal chemistry includes the study of drugs that target the heart and circulatory system. These drugs may be used to treat hypertension, heart failure, arrhythmias, or other conditions.
Immunomodulatory Medicinal Chemistry: Immunomodulatory medicinal chemistry focuses on drugs that modify the immune system's response. These drugs are used to treat autoimmune diseases, allergies, and organ transplant rejection.
Neuropharmacology: Neuropharmacology involves the study of drugs that target the central and peripheral nervous systems. These drugs treat neurological conditions like Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy, and chronic pain.
Psychotropic Medicinal Chemistry: Psychotropic medicinal chemistry focuses on drugs used to treat psychiatric disorders such as anxiety, depression, bipolar disorder, schizophrenia, and addiction.
Metabolic Disorder Medicinal Chemistry: Metabolic disorder medicinal chemistry involves the discovery and development of drugs that target endocrine disorders such as diabetes, thyroid disorders, and osteoporosis.
Pain Management Medicinal Chemistry: Pain management medicinal chemistry involves the discovery and development of drugs that target pain receptors or modify the perception of pain.
"Medicinal chemistry involves the identification, synthesis, and development of new chemical entities suitable for therapeutic use."
"It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR)."
"Medicinal chemistry is a highly interdisciplinary science combining organic chemistry with biochemistry, computational chemistry, pharmacology, molecular biology, statistics, and physical chemistry."
"Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules and 'biologics.'"
"e.g., atorvastatin, fluticasone, clopidogrel"
"e.g., infliximab, erythropoietin, insulin glargine"
"Medicines can also be inorganic and organometallic compounds, commonly referred to as metallodrugs."
"The discipline of Medicinal Inorganic Chemistry investigates the role of metals in medicine (metallotherapeutics), which involves the study and treatment of diseases and health conditions associated with inorganic metals in biological systems."
"There are several metallotherapeutics approved for the treatment of cancer, antimicrobials, diabetes, broad-spectrum antibiotic, bipolar disorder."
"Other areas of study include: metallomics, genomics, proteomics, diagnostic agents, and radiopharmaceuticals."
"Medicinal chemistry in its most common practice—focusing on small organic molecules—encompasses synthetic organic chemistry and aspects of natural products and computational chemistry in close combination with chemical biology, enzymology, and structural biology."
"Together aiming at the discovery and development of new therapeutic agents. Practically speaking, it involves chemical aspects of identification and then systematic, thorough synthetic alteration of new chemical entities to make them suitable for therapeutic use."
"Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products."
"At the biological interface, medicinal chemistry combines to form a set of highly interdisciplinary sciences, setting its organic, physical, and computational emphases alongside biological areas such as biochemistry, molecular biology, pharmacognosy and pharmacology, toxicology, and veterinary and human medicine."
"These, with project management, statistics, and pharmaceutical business practices, systematically oversee altering identified chemical agents such that after pharmaceutical formulation, they are safe and efficacious, and therefore suitable for use in the treatment of disease."