- "A natural product is a natural compound or substance produced by a living organism—that is, found in nature." - "In the broadest sense, natural products include any substance produced by life." - "Natural products can also be prepared by chemical synthesis and have played a central role in the development of the field of organic chemistry." - "The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients."
The study of medicines derived from natural sources like plants, marine organisms, and microorganisms.
Introduction to Natural Products: This topic explores the concept of natural products, their classification, structure, and roles in medicinal chemistry.
Isolation and Characterization of Natural Products: This topic covers various methods used for the identification and extraction of natural products from different sources such as plants, animals, or bacteria.
Biosynthesis of Natural Products: This topic talks about the metabolic pathways involved in the biosynthesis of natural products and how they can be manipulated to produce new compounds.
Pharmacognosy: This topic discusses the pharmacological properties of natural products, their mechanism of action, and their applications in modern medicine.
Structure-Activity Relationship (SAR): This topic explores the relationship between the structure of natural products and their biological activity. It helps to understand how small changes in the structure of a natural product can result in changes in its pharmacological activity.
Natural Product-based Drug Design: This topic discusses the utilization of natural products as templates for drug design and development. It includes various approaches used for the development of natural product-based drugs.
Modern Approaches for Natural Product-based Drug Discovery: This topic talks about the modern approaches and tools used for the discovery and development of natural product-based drugs, such as High throughput Screening (HTS), combinatorial chemistry, and computer-aided drug design (CADD).
Natural Product-based Anticancer Agents: This topic explores the role of natural products in cancer treatment, their use as chemopreventive agents, and their mechanisms of action against cancer cells.
Natural Product-based Antimicrobial Agents: This topic discusses the role of natural products in fighting against bacterial, viral, and fungal infections.
Natural Product-based Nootropic Agents: This topic talks about the use of natural products in enhancing cognitive functions, such as memory, learning, and attention.
Natural product-based Anti-Inflammatory Agents: This topic explores the role of natural products as anti-inflammatory agents and their mechanisms of action.
Natural Product-based Neuroprotective Agents: This topic discusses the use of natural products in protecting the nervous system against various diseases such as Alzheimer's and Parkinson's disease.
Structural Modification of Natural Products: This topic explores the different methods used for modifying the structure of natural products to improve their pharmacological properties.
Toxicology of Natural Products: This topic talks about the safety and toxicity issues associated with the use of natural products as drugs.
Clinical Trials and Regulatory Issues: This topic discusses the various phases of clinical trials involved in the development of natural product-based drugs and the regulatory issues associated with their approval.
Alkaloids: These are nitrogen-containing compounds commonly derived from plants and have diverse pharmacological activities. Example: Morphine.
Terpenoids: These are isoprene-derived compounds found in plants, animals, and microorganisms. They have diverse pharmacological activities and can act as anticancer, antimalarial, and anti-inflammatory agents. Example: Taxol.
Flavonoids: These are phenolic compounds found in fruits, vegetables, and other plant sources. They possess antioxidant, antiviral, and anti-inflammatory properties. Example: Quercetin.
Glycosides: These are compounds composed of a sugar molecule and a non-sugar molecule. They exhibit various pharmacological activities and are commonly found in medicinal plants. Example: Digoxin.
Antibiotics: These are natural or synthetic compounds that kill or inhibit the growth of bacteria. Examples: Penicillin, Tetracycline.
Peptides: These are short chains of amino acids that exhibit diverse biological activities. They have been explored for their use in treating cancer and infectious diseases. Example: Linaclotide.
Steroids: These are lipids that are essential in the body's hormonal regulation. They are derived from plants and animals and exhibit various biological activities. Example: Prednisone.
Lignans: These are organic compounds found in plants that possess antioxidant and anticancer properties. Example: Enterodiol.
- "Natural products have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets."
- "Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism." - "Secondary metabolites (or specialized metabolites) are not essential for survival, but nevertheless provide organisms that produce them an evolutionary advantage."
- "Secondary metabolites are often unique to species, which is contrasted to primary metabolites which have broad use across kingdoms." - "Secondary metabolites are marked by chemical complexity which is why they are of such interest to chemists."
- "Many secondary metabolites are cytotoxic and have been selected and optimized through evolution for use as 'chemical warfare' agents against prey, predators, and competing organisms."
- "Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery."
- "Due to unreliable access and supply, intellectual property, cost, and profit concerns, seasonal or environmental variability of composition, and loss of sources due to rising extinction rates."
- "The term natural product has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients."
- "Unreliable access and supply, intellectual property, cost, and profit concerns, seasonal or environmental variability of composition, and loss of sources due to rising extinction rates."
- "Secondary metabolites (or specialized metabolites) are not essential for survival, but nevertheless provide organisms that produce them an evolutionary advantage."
- "Secondary metabolites are marked by chemical complexity which is why they are of such interest to chemists."
- "Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery."
- No specific quote directly answers this question.
- "Secondary metabolites (or specialized metabolites) are not essential for survival, but nevertheless provide organisms that produce them an evolutionary advantage."
- "Due to unreliable access and supply, intellectual property, cost, and profit concerns, seasonal or environmental variability of composition, and loss of sources due to rising extinction rates."
- "Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites."
- "Natural products have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets."
- "Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis)."
- "Due to unreliable access and supply, intellectual property, cost, and profit concerns, seasonal or environmental variability of composition, and loss of sources due to rising extinction rates."
- "Many secondary metabolites are cytotoxic and have been selected and optimized through evolution for use as 'chemical warfare' agents against prey, predators, and competing organisms."