"Immunogenetics or immungenetics is the branch of Medical Immunology and Medical Genetics that explores the relationship between the immune system and genetics."
The study of the genetic basis of the immune system and its responses.
Immunology: Basic concepts of the immune system, including innate immunity and adaptive immunity, different types of immune cells and their functions, and the role of cytokines and chemokines.
Genetics: Basic concepts of genetics, including genes, chromosomes, DNA structure, replication, transcription, and translation.
HLA system: The major histocompatibility complex (MHC), which codes for proteins called human leukocyte antigens (HLA) that play an essential role in the immune system.
Antigen processing and presentation: The process by which antigens are broken down and presented by MHC molecules to immune cells.
T cell receptors: The structure and function of T cell receptors (TCRs), including how they specifically recognize antigens presented by MHC molecules.
B cell receptors: The structure and function of B cell receptors (BCRs), including how they specifically recognize antigens and initiate an immune response.
Antibodies: The structure and function of antibodies, including how they recognize and neutralize antigens.
Immune response: How the immune system responds to different types of pathogens, including bacteria, viruses, and parasites.
Immunodeficiencies: Genetic disorders that impair the function of the immune system, including primary immunodeficiencies and acquired immunodeficiencies.
Autoimmunity: The phenomenon of the immune system attacking the body's own cells and tissues, leading to autoimmune diseases.
Allergy: The phenomenon of hypersensitivity to environmental antigens, leading to allergic reactions.
Transplantation: The compatibility between donor and recipient tissues, including the immune responses and HLA matching.
Vaccination: The development of vaccines and their effectiveness in preventing infectious diseases.
Cancer immunotherapy: The use of the immune system to target and eliminate cancer cells.
Next-generation sequencing: The use of high-throughput DNA sequencing technologies to analyze genetic variation and identify disease-causing mutations.
Epigenetics: The study of changes in gene expression that are not caused by changes in the DNA sequence, including DNA methylation and histone modification.
"Autoimmune diseases, such as type 1 diabetes, are complex genetic traits which result from defects in the immune system."
"Identification of genes defining the immune defects may identify new target genes for therapeutic approaches."
"Genetic variations can also help to define the immunological pathway leading to disease."
"Immunogenetics explores the relationship between the immune system and genetics."
"Immunogenetics or immungenetics is the branch of Medical Immunology and Medical Genetics."
"Autoimmune diseases, such as type 1 diabetes..."
"Autoimmune diseases are complex genetic traits..."
"Identification of genes defining the immune defects may identify new target genes for therapeutic approaches."
"Genetic variations can also help to define the immunological pathway leading to disease."
"The focus of immunogenetics is exploring the relationship between the immune system and genetics."
"The purpose of studying immunogenetics is to understand the relationship between the immune system and genetics."
"Defects in the immune system can result in autoimmune diseases."
"Identification of genes defining the immune defects may identify new target genes for therapeutic approaches."
"Genetic research can contribute to improving treatment options by identifying new target genes for therapeutic approaches."
"Immunogenetics can study complex genetic traits such as autoimmune diseases like type 1 diabetes."
"Immunogenetics overlaps with Medical Immunology and Medical Genetics."
"Genetic variations can help define the immunological pathway leading to disease."
"Understanding immunogenetics can lead to personalized medicine through targeted therapeutic approaches based on specific genetic defects."
"The presence of defects in the immune system due to genetic traits can lead to autoimmune diseases."