It is activated by the binding of mannose-binding lectin (MBL) or ficolins to carbohydrates on a pathogen's surface. This recruits MBL-associated serine proteases (MASPs) to cleave C4 and C2, leading to the formation of the C3 convertase.
It is activated by the binding of mannose-binding lectin (MBL) or ficolins to carbohydrates on a pathogen's surface. This recruits MBL-associated serine proteases (MASPs) to cleave C4 and C2, leading to the formation of the C3 convertase.