"Pharmacogenomics is the study of the role of the genome in drug response."
Pharmacogenomics refers to the study of how a person's genetics can influence their response to drugs.
Genetics: Study of genes, inheritance, and gene expression.
Genomics: Study of the genome and its function in the organism.
Pharmacology: Study of drugs and their effects on the body.
Pharmacokinetics: Study of drug absorption, distribution, metabolism, and excretion in the body.
Pharmacodynamics: Study of the interaction between drugs and their targets in the body.
Drug metabolism: Study of the enzymes and pathways involved in the metabolism of drugs by the body.
Drug transporters: Study of the proteins involved in the transport of drugs across cell membranes in the body.
Drug targets: Study of the proteins and molecular pathways targeted by drugs in the body.
Personalized medicine: Use of genomic and other molecular data to tailor medical treatments to individual patients.
Clinical trials: Controlled studies that test the safety and efficacy of new drugs in humans.
Bioinformatics: Use of computational methods to analyze and interpret genomic and other molecular data.
Precision medicine: Use of genomic and other molecular data to identify the best treatments for particular patients or patient groups.
Ethical, legal, and social implications (ELSI) of pharmacogenomics: Study of the ethical, legal, and social issues related to the use of genomic and other molecular data in medicine.
Drug discovery and development: Process of discovering and developing new drugs for clinical use.
Drug Metabolism Genomics: The study of genetic variability that affects the metabolism of drugs in the body.
Drug Transporter Genomics: The study of genetic variability that affects the transport of drugs across cell membranes, affecting drug efficacy and toxicity.
Drug Target Genomics: The study of genetic variability that affects the pharmacodynamic response to drugs by binding at the target sites.
Drug Toxicity Genomics: The study of genetic variability that affects the susceptibility to adverse drug reactions and side effects.
Drug Response Genomics: The study of genetic variability that affects drug response and treatment outcomes, including the influence of polymorphisms on drug effectiveness.
Drug Dosage Genomics: The study of genetic variability that affects the optimal dosage of drugs leading to individualized drug therapy.
Personalized Medicine: The integration of multiple types of pharmacogenomics to tailor medical treatments to individual genetic profiles.
"Pharmacogenomics analyzes how the genetic makeup of a patient affects their response to drugs."
"Pharmacogenomics correlates DNA mutations with pharmacokinetic, pharmacodynamic, and/or immunogenic endpoints."
"Pharmacogenomics aims to develop rational means to optimize drug therapy, with regard to the patients' genotype, to achieve maximum efficiency with minimal adverse effects."
"Pharmacogenomics deviates from the 'one-dose-fits-all' approach by optimizing drug treatments based on the patients' genotype."
"Pharmacogenomics attempts to eliminate trial-and-error in prescribing, allowing physicians to take into consideration their patient's genes and how this may affect the efficacy of treatments."
"Such approaches promise the advent of precision medicine and even personalized medicine, in which drugs and drug combinations are optimized for narrow subsets of patients or even for each individual's unique genetic makeup."
"It hopes to achieve better treatment outcomes and greater efficacy, and reduce drug toxicities and adverse drug reactions (ADRs)."
"For patients who do not respond, alternative therapies can be prescribed that would best suit their requirements."
"Two possible types of input can be used: genotyping, or exome or whole genome sequencing."
"Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon)."
"It deals with the influence of acquired and inherited genetic variation on drug response."
"Pharmacogenomics aims to develop rational means to optimize drug therapy."
"Pharmacogenomics promises the advent of precision medicine and even personalized medicine."
"Pharmacogenomics focuses on the role of the genome in drug response."
"Pharmacogenomics correlates DNA mutations with pharmacokinetic, pharmacodynamic, and/or immunogenic endpoints."
"Pharmacogenomics aims to explain a patient's response (or lack of it) to a treatment."
"Pharmacogenomics aims to deviate from the 'one-dose-fits-all' approach."
"Pharmacogenomics attempts to reduce drug toxicities and adverse drug reactions (ADRs)."
"Pharmacogenomics allows physicians to take into consideration a patient's genes and their functionality to enhance the efficacy of their current or future treatments."